Ache

This time we are looking on the crossword puzzle clue for: Ache.
it’s A 4 letters crossword definition.
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Possible Answers:

PAIN.

Last seen on: –USA Today Crossword – Jan 12 2022
LA Times Crossword 2 Sep 19, Monday

Random information on the term “Ache”:

Barry W. Ache is an American neuroscientist currently a Distinguished Professor of Biology and Neuroscience at Whitney Laboratory for Marine Bioscience, University of Florida.

Ache on Wikipedia

Random information on the term “PAIN”:

Pain or Oh Pain, Little Pain, Pain (Spanish: ¡Ay, pena, penita, pena!) is a 1953 Mexican-Spanish musical comedy film directed by Miguel Morayta and starring Lola Flores, Luis Aguilar and Antonio Badú.

PAIN on Wikipedia