Discomfort cause

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it’s A 16 letters crossword definition.
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Last seen on: LA Times Crossword 24 Nov 21, Wednesday

Random information on the term “PAIN”:

Pain or Oh Pain, Little Pain, Pain (Spanish: ¡Ay, pena, penita, pena!) is a 1953 Mexican-Spanish musical comedy film directed by Miguel Morayta and starring Lola Flores, Luis Aguilar and Antonio Badú.

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PAIN on Wikipedia