Four-letter U.S. city with the highest population

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it’s A 49 letters crossword definition.
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Possible Answers:

MESA.

Last seen on: NY Times Crossword 23 Jun 19, Sunday

Random information on the term “MESA”:

Mesa is a town in Ancuabe District in Cabo Delgado Province in northeastern Mozambique.

It is located south-west of the district capital of Ancuabe.

MESA on Wikipedia