Gives the boot

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Possible Answers:

CANS.

Last seen on: –Thomas Joseph – King Feature Syndicate Crossword – Jun 23 2022
LA Times Crossword 3 Jan 21, Sunday
The Washington Post Crossword – Jan 3 2021
NY Times Crossword 13 Jun 19, Thursday

Random information on the term “CANS”:

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a hypothesis that there exists a subset of children with rapid onset of obsessive-compulsive disorder (OCD) or tic disorders and these symptoms are caused by group A beta-hemolytic streptococcal (GABHS) infections. The proposed link between infection and these disorders is that an initial autoimmune reaction to a GABHS infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations. It has been proposed that this autoimmune response can result in a broad range of neuropsychiatric symptoms. PANDAS is a subset of the pediatric autoimmune neuropsychiatric syndrome (PANS) hypothesis.

The PANDAS hypothesis was based on observations in clinical case studies at the US National Institutes of Health and in subsequent clinical trials where children appeared to have dramatic and sudden OCD exacerbations and tic disorders following infections. There is supportive evidence for the link between streptococcus infection and onset in some cases of OCD and tics, but proof of causality has remained elusive. The PANDAS hypothesis is controversial; whether it is a distinct entity differing from other cases of Tourette syndrome (TS)/OCD is debated.

CANS on Wikipedia