Ian McKellen and others, title-wise

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Possible Answers:

SIRS.

Last seen on: Universal Crossword – Oct 11 2021

Random information on the term “SIRS”:

Systemic inflammatory response syndrome (SIRS), is an inflammatory state affecting the whole body. It is the body’s response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an “inflammatory” response, it actually has pro- and anti-inflammatory components.

SIRS is frequently complicated by failure of one or more organs or organ systems. The complications of SIRS include

The causes of SIRS are broadly classified as infectious or noninfectious. Causes of SIRS include:[citation needed]

Other causes include:

SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure. It is a subset of cytokine storm, in which there is abnormal regulation of various cytokines. SIRS is also closely related to sepsis, in which patients satisfy criteria for SIRS and have a suspected or proven infection.

SIRS on Wikipedia