Made a hole

This time we are looking on the crossword puzzle clue for: Made a hole.
it’s A 11 letters crossword definition.
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Possible Answers:

DUG.

Last seen on: –Wall Street Journal Crossword – August 08 2022 – Secret Agents
Wall Street Journal Crossword – August 07 2022 – Secret Agents
Wall Street Journal Crossword – August 06 2022 – Secret Agents

Random information on the term “DUG”:

Double-stranded uracil-DNA glycosylase (EC 3.2.2.28, Mug, double-strand uracil-DNA glycosylase, Dug, dsUDG, double-stranded DNA specific UDG, dsDNA specific UDG, UdgB, G:T/U mismatch-specific DNA glycosylase, UDG) is an enzyme with systematic name uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing). This enzyme catalyses a specific chemical reaction: it hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil.

This enzyme is not active on DNA containing a T/G mispair or single-stranded DNA.

This EC 3.2 enzyme-related article is a stub. You can help Wikipedia by expanding it.

DUG on Wikipedia