This time we are looking on the crossword puzzle clue for: Bad habit.
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Last seen on: Universal Crossword – Jun 13 2019
Random information on the term “Bad habit”:
Addiction is a brain disorder characterized by compulsive engagement in rewarding stimuli despite adverse consequences. Despite the involvement of a number of psychosocial factors, a biological process – one which is induced by repeated exposure to an addictive stimulus – is the core pathology that drives the development and maintenance of an addiction. The two properties that characterize all addictive stimuli are that they are reinforcing (i.e., they increase the likelihood that a person will seek repeated exposure to them) and intrinsically rewarding (i.e., they are perceived as being inherently positive, desirable, and pleasurable).
Addiction is a disorder of the brain’s reward system which arises through transcriptional and epigenetic mechanisms and develops over time from chronically high levels of exposure to an addictive stimulus (e.g., eating food, the use of cocaine, engagement in sexual activity, participation in high-thrill cultural activities such as gambling, etc.). DeltaFosB (ΔFosB), a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions. Two decades of research into ΔFosB’s role in addiction have demonstrated that addiction arises, and the associated compulsive behavior intensifies or attenuates, along with the overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens. Due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.[note 1]
Bad habit on Wikipedia
Random information on the term “VICE”:
The Commodore 64, also known as the C64 or the CBM 64, is an 8-bit home computer introduced in January 1982 by Commodore International (first shown at the Consumer Electronics Show, in Las Vegas, January 7–10, 1982). It has been listed in the Guinness World Records as the highest-selling single computer model of all time, with independent estimates placing the number sold between 10 and 17 million units. Volume production started in early 1982, marketing in August for US$595 (equivalent to $1,545 in 2018). Preceded by the Commodore VIC-20 and Commodore PET, the C64 took its name from its 64 kilobytes (65,536 bytes) of RAM. With support for multicolor sprites and a custom chip for waveform generation, the C64 could create superior visuals and audio compared to systems without such custom hardware.
The C64 dominated the low-end computer market for most of the 1980s. For a substantial period (1983–1986), the C64 had between 30% and 40% share of the US market and two million units sold per year, outselling IBM PC compatibles, Apple computers, and the Atari 8-bit family of computers. Sam Tramiel, a later Atari president and the son of Commodore’s founder, said in a 1989 interview, “When I was at Commodore we were building 400,000 C64s a month for a couple of years.” In the UK market, the C64 faced competition from the BBC Micro and the ZX Spectrum, but the C64 was still one of the two most popular computers in the UK.
VICE on Wikipedia