Playbill heading

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Last seen on: NY Times Crossword 12 Jan 22, Wednesday

Random information on the term “CAST”:

The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized, controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality. It was conducted between 1986 and 1989 and included over 1700 patients in 27 centres. The study found that the tested drugs increased mortality instead of lowering it as was expected. The publication of these results in 1991/92, in combination with large follow-up studies for drugs that had not been tested in CAST, led to a paradigm shift in the treatment of MI patients. Class I and III antiarrhythmics are now only used with extreme caution after MI, or they are contraindicated completely. Heart Rhythm Society Distinguished Scientist D. George Wyse was a member of the CAST trial’s steering and executive committees.

The study was prompted by the fact that patients who suffer from myocardial infarctions (MIs) have a high risk of sudden death, presumably due to arrhythmia. Around the time of the study onset (1986), an estimated 8 to 15% of patients would die in the subsequent year following an MI, with about half of those deaths resulting from arrhythmia. This warranted the investigation as to whether PVC suppression could improve outcomes in post-MI patients. The trial was conducted by the National Heart, Lung, and Blood Institute.

CAST on Wikipedia