Quiet down over there!

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it’s A 22 letters crossword definition.
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Possible Answers:

Shh.

Last seen on: Daily Celebrity Crossword – 6/4/19 TV Tuesday

Random information on the term “Shh”:

3HO5, 3M1N, 3MXW

6469

20423

ENSG00000164690

ENSMUSG00000002633

Q15465

Q62226

NM_000193NM_001310462

NM_009170

NP_000184NP_001297391

NP_033196

Sonic hedgehog is a protein that in humans is encoded by the SHH (“sonic hedgehog”) gene. Both the gene and the protein may also be found notated alternatively as “Shh”.

Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert’s French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers.

Shh on Wikipedia